Mechanism

Vascular permeability and fluid-balance modulation

Proposed modulation of vascular permeability, capillary integrity and extracellular fluid accumulation in peri-orbital skin.

Use cautious wording for cosmetic puffiness claims and avoid treating medical oedema.

Biological pathway

Cosmetic claims for acetyl tetrapeptide-5 include reduced glycation and oedema-related fluid retention.

00b

Published peptide-specific clinical evidence is sparse and largely formulation- or supplier-associated.

00c

Mechanism and efficacy remain insufficiently confirmed by independent controlled studies.

Intermedin is an endogenous signalling peptide with physiological relevance; therapeutic administration remains molecule- and indication-specific.

A cosmetic peptide marketed for under-eye puffiness and dark circles. Independent peptide-specific clinical evidence is insufficient.

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from the knowledge graph

Peptides that touch this

Conditions in scope